There are a couple of riders who I thought might be looking for overall highish placings who are already in a significant hole and are pretty much stage hunting now. I nominate Chris Horner, Chris Froome, Peter Velits, and Richie Porte. Others who wouldn't be completely tranquillo: Schleck, Leipheimer, Sanchez, Kiserlovski, Coppel.
Its one thing to be 40 secs down on yellow in the first week. Its another thing to be already 40 secs down on Wiggins, Evans, Menchov and Nibali! Planning on making up time where exactly?