Time for that American staple: a finishing circuit race. Actually, a 10km course in a major city is no small accomplishment, and if it goes through the old Italian neighborhood (wherever that is), then I will officially endorse this course. Who will win is anyone's guess, though I'd cross off Hincapie, he'll be sitting comfortably in the field protecting his lead. Leipheimer will likely be active, with his US Champs' jersey and little else to do this season. Best bet would be that the winner comes from one of the continental teams: there will be breakaways, the course isn't very long or hard, and with the right combination there would be no reason to chase.
Enjoy!